Immunological Features of Measles in Children

Background: Despite the availability of a safe and effective vaccine, measles remains endemic in many countries is main cause morbidity mortality among young children. Therefore, objective study was to investigate immunological features Materials Methods: The immune status children (n = 72) who were diagnosed with measles, analysed. Various lymphocyte proportions determined using monoclonal antibodies immunofluorescence microscopy. immunoregulatory index calculated. Results: relative content CD4+ CD8+ T cells experimental group comprising moderately severely ill patients significantly lower. reduced, there positive correlation (0.3) between indices during admission (2.0469 ± 0.04830) entire hospital stay (1.9258 0.09099) patients, respectively. proportion CD16+ higher at rate increase cell (P < 0.05). counts moderate severe cases. Thus, exhibited T-cell deficiency. Conclusion: severity directly correlated patient age, disease progressing younger (r -0.3).